Showing posts with label Grof. Show all posts
Showing posts with label Grof. Show all posts

Monday, 17 October 2011

EPISODE 24: ON GIVING ENTHEOGENS TO CANCER PATIENTS




Welcome to my blog which on a weekly basis either updates my envious readers on my authorial life or, as is this case this week, admits there has been no evident activity on the publishing front (Chris! I’m beginning to hate you) and instead drifts on to other matters of parochial concern. Having spent 2 weeks on spirituality, I mean religion, I was intending to abjure that topic for the day but I haven’t quite managed owing to that report on magic mushrooms in last week’s Oberver.


Somewhere in a field near here on this overcast but not too cold morning, various people will be walking around with their eyes looking down in search of the psilocibin mushroom. I’ve done it myself – though not for forty years. At first it can be difficult to spot them and you find yourself picking ones which are similarly coloured but not quite the right shape. What you need then is someone more experienced to shake their head and save your stomach. After a while the mushies just pop up and offer themselves and you can’t quite believe that you missed them before and if you’ve just been reading your Carlos Castenada you are already half-way into a liminal state.

I don’t suppose the fifty of so roomies who took psilocybin under the guidance of John Hopkins University in 2002 culled their own mushrooms one sunny early morning in some dew-soaked cow-padded sacred site, nevertheless, judging by their reports, they certainly got to experience some extraordinary states of mind. The university are now looking for (depressed) cancer suffering volunteers on whom to experiment although the terms of inclusion are so exclusive I’m not sure how successful they’ll be in finding people.

The recent press reports focussed on the personality changes in the subjects and how they had become ‘more open’ despite being of an age, i.e. my age, where openness wasn’t to be expected (sic). The greatest changes came in those who had had ‘mystical’ experiences, those carrying the characteristics I mentioned a couple of chapters ago as identified by William James and the great Walter Pahnke, the originator of the Good Friday experiment which gave LSD to Divinity Students, namely:


1. Sense of Unity
2. Transcendence of Time and Space
3. Deeply felt positive mood
4. Sense of awe and reverence
5. Meaningfulness of psychological and or philosophical insights
6. Paradoxicality
7. Ineffability
8. Transiency
9. Persisting positive changes in attitude and behaviour.

Before I go on…is it or is it not strange that the hoped for benefits of this trial is (as put forward by the press) that it will somehow ameliorate the sufferings of cancer rather than produce a soma that delivers divinity? Does this not show the preferences of our culture?

Valentina Pavalovca Wasson
In 1955 a Russian woman called Valentina Pavalovca Wasson ate magic mushrooms with a Mexican Witch of the Mazatek tribe and it was she who first suggested, in 1957, that hallucinogenic experience could ease the pains of dying and that the mystical experience could cause entirely new understandings of religion and death. Her husband, also an anthropologist, coined the word ‘entheogenic’ for plant substances that promote the experience of ‘the divinity within’. Out of this, and the works of Jung, Campbell etc, came the trans-cultural theory of religion that claimed the foundation of religion was a non-ordinary state of consciousness inspired by entheogens or other practises designed to produce mystical states, eg, fasting, ritual, music, chanting.

In 1964 Eric Kast of the Chicago Medical School gave LSD to 128 patients with metastic cancer. There was no therapeutic intervention and the patients weren’t even told they were on LSD. Kast noted significance decreases in pain and less concern with imminent death. The patients’ carers also showed significant decreases in anxiety.

In Maryland another set of experiments took place at the Spring Grove Hospital beginning in the mid 60s, this time undertaken by doctors who had personal experience of LSD. A program applying LSD to alcoholics was amazingly successful with something like two thirds of those who had a ‘mystical’ or ‘peak’ experience renouncing the drink. (A study giving ketamine to alcoholics in Russia has had similar results.) From this it was theorized that alcoholism is a search for transcendence.

Next the doctors turned to the terminally ill cancer patients and provided a program for 60 of them with a view to measuring the effects on pain relief, levels of emotional distress, acceptance of death and fear of death, hierarchy of basic values and philosophic/religious  orientation. A third showed great improvement in all these measures, a third some improvement and a third no obvious change.


As predicted the greatest change came in those who had mystical, or peak, experiences. In 1973 Grof wrote:

The phenomenology of the individual sessions covered a very wide range from aesthetic experience of an abstract nature through reliving of traumatic or positive childhood memories to profound transcendental experiences of a mystical and religious nature. It has been our impression that most dramatic therapeutic changes followed sessions in which the patient achieved an intense psychedelic experience – an experience of unity, most frequently preceded by profound experiences of agony, death and rebirth.’ 

Stanislav Grof, who conducted much of this program, was very struck by this last point and noted, ‘That these changes’, (i.e. in values, depression and fear of death) ‘did not come from an ontological or religious belief about life after death but as the direct experience of experiencing death in their own psyche.’ He also noted that family and partners of a dying person who had taken the phantasticum was often so impressed that they asked to take the drug themselves.

Remember that these patients were so seriously ill and terminal that a few of them signed the consent forms even though they were too ill to take the personality tests.

In 1973 psychedelic therapy was ended owing to political idiocy.

Forty years pass and where have we got to? Nowhere. So good luck to John Hopkins.

Monday, 19 September 2011

EPISODE 20: ON SATIVEX, CANCER, MEDICAL MARIJUANA AND GOVERNMENTAL CONTROL OF PAIN RELIEF.

Welcome to my blog which this week which this week has been distracted by a friend, a cancer sufferer, who mentioned who said he'd asked his doctor for the drug, sativex, and been given short shrift.Maybe it would have been different if he had lived in Manchester because in the last couple of weeks, Sativex, a drug produced by GW Pharmaceuticals who are ‘sponsoring’ trials in two hospitals in Manchester, has received plenty of publicity as a potential palliative pain preventative for cancer sufferers.

Sativex® is composed primarily of two cannabinoids: CBD (cannabidiol,) and THC (delta 9 tetrahydrocannabinol). Sativex® is administered as a metered dose oro-mucosal spray each 100μL spray contains 2.7mg THC and 2.5mg CBD.
 
GW Pharmaceuticals have been attempting to produce marijuana based medicines since 1999 and Sativex is already widely proscribed to Multiple Sclerosis although the evidence for its success seems, at first sight, unconvincing. According to the MS Society’s leaflet on Sativex:

The way cannabinoids work is not fully understood as yet, but discovery of the endocannabinoid system – a natural system found in the human body through which cannabinoids are able to exert their effects – has provided some insight.
The endocannabinoid system is thought to work in a similar way to the opioid system – the system that controls pain. Some pain-killing medicines exert their effects on opioid receptors to provide relief from pain. In a similar way, cannabinoids exert their effects on cannabinoid receptors that are part of the endocannabinoid system.
Receptors are protein molecules in or on the surface of cells to which a substance (such as a drug) can bind, causing a change in cell behaviour or activity. The specific receptors that the active ingredients of Sativex (THC and CBD) exert their effects upon are the CB1 receptor and the CB2 receptor. CB1 receptors are thought to exert their effects in the brain while CB2 receptors are thought to exert their effects on immune cells.

There’s a lot of ‘it is thought’ about this and one can only imagine that a very persuasive voice, or a very desperate situation, has allowed this through as ‘evidence-based’ medicine. Personally I’m all in favour of the trials, not least because I have a friend who may benefit, but I am disturbed, and perhaps irritated, by governmental obfuscation concerning drugs, especially cannabis. How is it, for example, that GM Pharmaceuticals can don white coats and grow forests of marijuana secretly in the English countryside, while a pensioner who bakes some hash cake to self-medicate or a middle-aged depressive who smokes weed to cheer himself up will find themselves prosecuted or imprisoned? And why is that drinking alcohol (which is rarely recommended as a healing drug) is fine for Prime Ministers, sport people and ‘responsible’ drinkers when puffing on your marijuana joint is a criminal offence?

Cannabis has been used as a medicine since time immemorial in China, the Middle East, and probably everywhere it has grown. 

AIDS Wasting Syndrome
Arthritis
Brain Injury/Stroke
Multiple Sclerosis
Nausea associated with cancer Chemotherapy
Anti-Tumour Effects
Asthma
Epilepsy
Glaucoma
Schizophrenia
Migraine
Eating Disorders
General Pain

Are just some of the conditions that reputedly benefit from cannabis. If the smooth talkers at GM Pharmaceuticals play their cards right, the entire NHS could be at their mercy. Of course for most of our 15,000 year relationship with the plants around us, the general populace hasn’t needed the sanction of government to help itself to herbs and plants considered healing. Will there be a time when the application of a dock leaf to a nettle sting will have to be applied by an oral spray, Extract of Dock, administered only by a recognized government sponsored professional?

The Sativex publicity is keen to declare that Sativex “does not get users high” and patients do not experience the “euphoria associated with illegal recreational use of cannabis”. Now, I’m no scientist (although I am a Master of Science) and I have observed in other writers the tendency to run with a ‘scientific fact’ as long as it appears to support their worldview, so my brief look at the figures does not mean a lot, but it seems to be that 2.7mg THC and 2.5mg CBD is equivalent to approximately 1gram of marijuana. Depending on the strength of the marijuana, and on how accustomed you are to it, and on a host of other minor circumstances, 1 gram of cannabis would get you ‘stoned’ if not ‘high’, In fact, according to a number of sources that I’ve just checked, particularly Peter Reynolds http://clear-uk.org/the-sativex-scam-part-2-5/, it does indeed get you high. My problem with this is, why is getting high considered to be a bad thing? Isn’t the getting high bit essential to the healing? Is it not the case that whatever happens in the brain, and in the whole body (and in our consciousness if we have one) when we get high, is what is required molecularly to relieve the distress we’re in?


Candice Pert, neuroscientist and pharmacologist, has claimed that short chains of amino acids called peptides, and their receptors, are the "biochemical correlate of emotion." Peptides are found in the brain, but also in the stomach, muscles, glands and all the major organs. Her conclusion is that peptides in these other organs have memories – what she calls “the unconscious mind”. Since reaching these conclusions she has promulgated notions such as ‘change your mind, change your life,’ on the premise that, to paraphrase, that getting high, though not necessarily through drugs, is good for you. Surely it can’t be bad for you, so what’s the government’s problem? I guess it’s got to be power or money or both.


Meanwhile in California, and other states, we have some sort of compromise; medical marijuana available on prescription. Presumably this is the way forward. Or rather, the way we’re going to go in the long run unless GM Pharmaceuticals and their ilk can seize the supplies and monopolize the market with their potions. It could be, of course, that the government have foreseen a problem I have often wondered about, viz. how to please a generation of pensioners when we stick them in homes and deprive them of the one drug they’ve been medicating themselves with for the previous fifty years. Give them pot!


Or MDMA. I’m not joking. A variation of Ecstasy is being tested on blood cancers and early study showed all leukaemias, lymphoma and myeloma cells could be killed in a test tube. My brother has lymphoma. 


Or LSD. Still not joking. Stanislav Grof did some pioneering work with the dying, giving them LSD, back in the mid-sixties. His results were interesting but the tests had to be abandoned owing to the bad publicity LSD received from the media of the day.

My point? I don’t know yet but I don’t like the idea of David Cameron and his champaign boozing, cocaine taking friends to be in charge of anything, maybe  least of all of the THC supply of the dire and desperate.